Peroxisome Proliferator-Activated Receptor γ Ligands Stimulate Endothelial Nitric Oxide Production Through Distinct Peroxisome Proliferator-Activated Receptor γ–Dependent Mechanisms

Peroxisome Proliferator-Activated Receptor Ligands Stimulate Endothelial Nitric Oxide Production Through Distinct Peroxisome Proliferator-Activated Receptor –Dependent Mechanisms

Objective—We recently reported that the peroxisome proliferator-activated receptor (PPAR ) ligands 15-deoxyprostaglandin J2 (15d-PGJ2) and ciglitazone increased cultured endothelial cell nitric oxide (NO) release without increasing the expression of endothelial nitric oxide synthase (eNOS). The current study was designed to characterize further the molecular mechanisms underlying PPAR -ligand–s...

Peroxisome Proliferator-Activated Receptor

Peroxisome proliferator - activated receptor

The peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor superfamily. All PPARs heterodimerize with the retinoid X receptor (RXR) and bind to specific regions on the DNA of target genes. The discovery of PPARγ as a target of multimodal insulin sensitizers has attracted remarkable scientific interest and had a great impact on the pharmaceutical industry. Thi...

Peroxisome Proliferator-Activated Receptor

Peroxisome Proliferator-Activated Receptor Ligands Increase Release of Nitric Oxide From Endothelial Cells

From Endothelial Cells Ligands Increase Release of Nitric Oxide γ Peroxisome Proliferator-Activated Receptor Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2002 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/01.ATV.0000044461....